TD-IntelGel™ Technology — Needle-Free Buccal Peptide Delivery

The platform

What is TD‑IntelGel™?

TD‑IntelGel™ — trans‑diffusion intelligent gel — is a patented hydrogel delivery platform built around a single buccal dissolving patch. It holds a peptide against the lining of the inner cheek, protects it, and meters its release directly into systemic circulation.

NeoPep developed it to solve the oldest problem in peptide medicine: extraordinary molecules that are extraordinarily hard to deliver. Most peptides break down in the stomach or demand an injection — keeping them out of everyday reach.

The buccal route sidesteps both. The inner cheek is thin, richly supplied with blood, and drains straight into circulation — bypassing the digestive tract and the liver’s first‑pass metabolism entirely.

The result is a familiar, needle‑free format that behaves like an advanced delivery system: stable in storage, comfortable to use, and engineered for consistent, repeatable absorption.

Intelligent hydrogel

A smart matrix that stabilizes the peptide and controls how it releases.

Buccal delivery

Absorption through the inner cheek — not the stomach.

Needle-free

No injections, no sharps, no cold-chain anxiety.

Direct to bloodstream

Bypasses the gut and first-pass metabolism.

Inside the patch

See the tri-layer in motion.

A closer look at how the three engineered layers stabilise the peptide, control its diffusion across the buccal membrane, and hold the patch in place.

Watch: the TD‑IntelGel™ tri-layer hydrogel platform, layer by layer.

The challenge

Why traditional peptide delivery falls short.

Every conventional format solves one problem while creating another — which is exactly the gap TD‑IntelGel™ was built to close.

Painful injections

Inconvenient administration

Poor patient compliance

Peptide instability

First-pass metabolism loss

Cold-chain storage burden

Traditional peptide methods

The trade-offs you inherit

Needles, syringes & sharps disposal
Low patient adherence
Fragile in storage & transit
Degraded by the gut & liver
Oral bioavailability often 1–2%

NeoPep TD‑IntelGel™

The problems it closes

Needle-free buccal dissolving patch
Simple, comfortable, self-applied
Stabilized peptide matrix
Bypasses the gut & first-pass metabolism
Up to 90% relative delivery performance (human clinically tested)

vs

How it works

From cheek to bloodstream, in four steps.

1

Place

Place the buccal patch comfortably against the inside of the cheek. It adheres on contact.

2

Seal

Muco‑SmartSeal® keeps the patch securely attached to the buccal tissue.

3

Release

TD‑IntelGel™ controls the peptide’s release at a steady, repeatable rate.

4

Absorb

Peptides are absorbed through the buccal mucosa, straight into circulation.

Part of TD‑IntelGel™

Meet Muco‑SmartSeal®.

The adhesion layer that makes buccal delivery dependable. Muco‑SmartSeal® holds the patch against the moist inner cheek so the dose lands where it should — and stays there.

Secure adhesion — grips the mucosa so the patch doesn’t drift or get swallowed.
Comfortable wear — a thin, low-profile seal designed to be barely noticeable in use.
Controlled release — keeps a protected pocket against the tissue for steady delivery.
Better absorption — sustained contact maximizes how much peptide crosses the mucosa.

Buccal patchTD‑IntelGel™ peptide reservoir

Muco‑SmartSeal®Adhesion & protected pocket

Buccal tissueThin, blood-rich mucosa

AbsorptionDirect into the bloodstream

Why it’s different

Advanced buccal delivery, measured against the alternatives.

TD‑IntelGel™ combines intelligent hydrogel technology with a tri-layer buccal dissolving patch specifically designed to deliver high-molecular-size, temperature-sensitive and very fragile active ingredients such as peptides, vaccines, hormones and so on.

Human clinical studies comparing TD‑IntelGel™ buccal patches with peptides against injectables have shown extremely encouraging results, with efficacy near comparable to injection levels.

The TD-IntelGel buccal patch and buccal films shown alongside other peptide delivery formats — an injection vial and syringe, and oral capsules and tablets

TD‑IntelGel™ vs traditional injection delivery

While injections remain widely used, TD‑IntelGel™ introduces a needle‑free buccal approach designed around convenience, simplicity and user experience.

Feature	Traditional injection	TD‑IntelGel™ buccal patch
Delivery method	Injection using a needle	Needle-free buccal dissolving patch
User experience	May cause discomfort during administration	Designed for comfortable application inside the cheek
Ease of use	May require training or assistance	Simple placement inside the cheek
Administration	Requires injection equipment	Easy-to-use patch format
Disposal	Requires sharps disposal	No needles or sharps required
Portability	Requires syringes and accessories	Compact and portable patch
Technology platform	Conventional injection approach	TD‑IntelGel™ intelligent hydrogel platform
Muco‑SmartSeal®	Not applicable	Helps maintain patch placement on buccal tissue
Needle-free	No	Yes
Buccal delivery	No	Yes
Intelligent hydrogel	No	Yes
Patient convenience	Lower convenience	Designed for convenient application
Innovation	Traditional delivery method	Next-generation peptide delivery technology

Clinical evidence

Does the technology work? The data says yes.

TD‑IntelGel™ has been evaluated in human clinical studies that measure the bioavailability, or buccal absorption, of peptides — and proven to be extremely efficacious.

Measured, not asserted — delivery performance is quantified against injectables and oral dissolving strips.
Reproducible method — a standardized clinical model designed to reflect buccal absorption.
Documented for partners — study summaries available under partnership and NDA.

In vitro performance comparison

Tablets & capsulesVery poor or nil

Oral dissolving stripsVery poor — less than 10%

Injections / IVVery high — 90%, but needle-based

TD‑IntelGel™ buccal patchVery high — 65–90% (human clinically tested)

* Comparative delivery performance for peptides; performance may vary by peptide, formulation and study conditions.

Testing & validation

Tested and validated in three phases — in-vitro, pre-clinical and clinical.

1

Phase 01 · In-vitro studies

Permeation across a biomimetic barrier

TD‑IntelGel™’s buccal delivery was assessed using PermeaPad™, an industry-recognized biomimetic barrier for in-vitro permeation studies. PermeaPad™ models the buccal membrane, allowing repeatable measurement of how much peptide diffuses across it — the closest lab proxy to real buccal absorption before clinical work.

1
Prepare
Finished TD‑IntelGel™ patches and comparator formats are prepared under controlled conditions.
2
Mount on PermeaPad™
Each format is placed in the donor chamber against the biomimetic buccal barrier.
3
Measure permeation
Peptide crossing into the acceptor chamber is measured over time to quantify delivery.
4
Compare & document
Results are benchmarked against oral formats and captured in study documentation.

Patch & formulation

PermeaPad™

Permeated peptide measured

2

Phase 02 · Pre-clinical studies

Single-dose pharmacokinetics in vivo

The study evaluated the buccal absorption / bioavailability and pharmacokinetic profile of a TD‑IntelGel™ buccal peptide patch following a single administration, compared with an oral suspension and a subcutaneous injection, in male New Zealand White rabbits.

1
Prepare
TD‑IntelGel™ patches and comparator formats are prepared under controlled conditions.
2
Cohort
18 healthy New Zealand White rabbits fasted for 4 hours; feed provided 2 hours post-dosing.
3
Measure
TD‑IntelGel™ patch, oral suspension and SC injection dosed at set intervals and tested by LC‑MS/MS.
4
Compare
Results showed satisfactory outcomes across 70–90% efficacy levels.

3

Phase 03 · Clinical studies

Human study vs subcutaneous injection

An open-label, randomised, single-dose, two-treatment, parallel-group study evaluating the pharmacokinetics, local mucosal tolerability and safety of a buccal patch compared with subcutaneous injection in healthy adults.

1
Prepare
Tested, validated TD‑IntelGel™ patches and comparator formats are prepared under controlled conditions.
2
Cohort
16 subjects resident in the unit from at least 10 hours before dosing until the 24-hour assessment.
3
Measure
Validated LC‑MS/MS for peptide in human plasma; dose-normalised exposure ratios and coefficient of variation by treatment.
4
Result
All subjects showed a consistent absorption phase — median time-to-peak and mean maximum concentration corresponding to an estimated high absolute bioavailability.

In-vitro, pre-clinical and clinical results are indicative and may vary by peptide, formulation and study conditions. PermeaPad™ is a trademark of its respective owner.

Manufacturing process

Made cold, made carefully.

Peptides are sensitive. To protect their integrity, every NeoPep patch is produced through a controlled, low-temperature process below 8°C — from mixing through to finished, individually pouched product. This is a real, repeatable manufacturing operation, not a hobbyist bench.

1

Cold-mix (<8°C)

The peptide and hydrogel matrix are combined under a sub-8°C process to preserve bioactivity.

2

Tri-layer forming

The TD‑IntelGel™ tri-layer patch is formed with the Muco‑SmartSeal® adhesion layer.

3

Batch quality testing

Batches undergo quality and stability checks against defined specifications.

4

Individual pouching

Each patch is sealed in an individual protective foil pouch, ready for global B2B supply.

Controlled, low-temperature (<8°C) production

Batch quality & stability testing

Individual protective packaging

Patents & protection

Technology that’s hard to copy — by design.

TD‑IntelGel™ and Muco‑SmartSeal® are proprietary NeoPep platforms protected by patent and technology safeguards. For partners, that protection is strategic: a product built on NeoPep can’t simply be replicated by a competitor down the street.

Patented platform

TD‑IntelGel™ tri-layer hydrogel delivery.

Protected adhesion

Muco‑SmartSeal® mucoadhesive technology.

Defensible differentiation

A moat around your product line.

Documentation on request

Protection details shared with partners under NDA.

Technology features

Engineered end to end for peptide delivery.

TD-IntelGel buccal peptide patch — tri-layer hydrogel

Intelligent hydrogel platform

A smart, tri-layer matrix that stabilizes the peptide and meters its release — the engine behind every NeoPep patch.

Needle-free delivery

No injections, no sharps.

Buccal dissolving patch

Placed inside the cheek.

Enhanced adhesion

Muco-SmartSeal® grip.

Controlled release

Steady, repeatable rate.

<8°CCold-mix GMP manufacturing protects every peptide.

Peptide stability

Protected in storage & use.

Rapid absorption

Direct to the bloodstream.

Patient-friendly

Simple, comfortable, discreet.

Validation & quality

Built on evidence, documented for partners.

NeoPep’s commitment to quality runs through every stage — from laboratory validation to the paperwork our B2B partners need.

01Laboratory testing and validation
02Manufacturing quality processes
03Product stability & performance evaluation
04Certifications & compliance documentation
05Patent & technology protection
06Technical documentation for B2B partners

Applications

One platform, a full range of solutions.

The same TD‑IntelGel™ patch powers formulations across every category. Explore where the technology is applied — in peptides, vaccines, hormones, oncology and so on.

Peptides

Needle-free, high-bioavailability delivery of fragile, temperature-sensitive peptides.

Vaccines

A buccal route for temperature-sensitive vaccine formulations, without the cold-chain of injectables.

Hormones

Stable delivery for large-molecule and temperature-sensitive hormone therapies.

Oncology

Gentle, needle-free routes for sensitive oncology actives, developed with partners.

Advanced needle‑free buccal peptide delivery technology.