Research- & technology-driven peptide delivery

Peptides,
delivered beyond
pills & needles.

NeoPep is an innovation-driven company specializing in the research and manufacturing of needle-free, buccal-patch peptide delivery solutions.

Explore the platform See how it works

Patented Human Clinical Tested Needle-Free Hassle-Free

The problem

Why most peptides never reach the bloodstream.

Peptides are among the most precise tools in medicine — and among the hardest to deliver into the blood, which leads to low efficacy. For the clinics, pharmacies and brands dispensing them, patient compliance and ease of use are a constant hassle. Two roads, two operational headaches.

Oral strips, pills & capsules

Swallowed & destroyed

Poor buccal absorption — peptides are extremely large in size, very sensitive to heat, highly unstable, and degrade quickly when exposed to enzymes in saliva and the acidic juices of the stomach. They’re also very sensitive during mixing and manufacturing.

The needle

Painful & difficult to administer

Injections work — but the cost lands on your operation: cold‑chain storage, sharps handling and disposal, trained administration, and the adherence gap when patients avoid the needle between visits.

So we asked a simpler question:
what if the cheek could do the work of the needle?

Meet TD‑IntelGel™ buccal patch

A patented tri-layer hydrogel platform.

Three engineered layers deliver the fragile peptide across the cheek and into the blood — the buccal patch is sealed at the edges so nothing is lost into saliva.

The TD‑IntelGel™ tri-layer, sealed at the edges by Muco‑SmartSeal® — shown in motion.

HydroGel — Increased Buccal AbsorptionThe trans-diffusion intelligent gel

The TD‑IntelGel™ technology with hydrogel enables increased buccal absorption and preserves peptides within a hydrogel matrix, helping maintain molecular stability and biological activity throughout delivery.

Structural Support LayerControlled diffusion

Provides mechanical strength and sustained contact, supporting controlled peptide diffusion across the buccal membrane.

Muco‑SmartSeal — Adhesive LayerStays in place

Sealed at the edges by Muco‑SmartSeal® — maintaining prolonged contact with the mucosa and preventing peptide leakage into saliva. This positions the patch securely inside the buccal cavity for reliable, uninterrupted peptide delivery.

The Delivery Challenge

The Missing Piece in Peptide Therapeutics

Peptides have the potential to transform modern therapeutics. Delivering them efficiently has remained the industry’s greatest challenge. Existing delivery methods each solve one problem — while creating another.

Pills & Capsules

Easy to Take.
Difficult to Deliver.

Digestive enzymes and first-pass metabolism can degrade peptides before they reach systemic circulation, limiting their effectiveness.

Injections

Effective Delivery.
Limited Convenience.

While injections improve absorption, they remain invasive, uncomfortable and often reduce long-term patient compliance.

Conventional Oral Strips

Convenient.
But Not Optimized for Peptides.

Saliva exposure, limited stability and inconsistent buccal contact can reduce peptide retention and absorption.

The Science Inside

A Different Approach to Peptide Delivery

TD‑IntelGel™ is more than a buccal patch—it’s an integrated peptide delivery platform. By combining a patented tri‑layer hydrogel architecture, Muco‑SmartSeal® technology and an ultra‑gentle cold manufacturing process, it preserves peptide integrity while optimizing buccal delivery.

Tri-layer Architecture

A patented three‑layer hydrogel that stabilizes peptides and enables controlled, consistent buccal delivery.

Muco‑SmartSeal®

A proprietary seal that keeps the patch in secure buccal contact while minimizing peptide loss.

Cold Manufacturing (<8°C)

An ultra‑gentle process that preserves the structure and bioactivity of lyophilized peptides.

TD‑IntelGel™

Stable Lyophilized Peptides

Efficient Buccal Delivery

Injection‑Level Performance

Oral Convenience

How it works

From cheek to bloodstream in minutes.

Place

The patch is pressed gently to the inside of the cheek. It adheres on contact.

Seal

Muco‑SmartSeal® locks it against the mucosa in a protected pocket.

Absorb

The peptide crosses the thin, blood-rich buccal lining — skipping the stomach.

Deliver

It enters circulation directly, avoiding first‑pass metabolism in the liver.

Comparative Performance

A measurable difference in delivery.

Comparative data shows how much of the administered peptide reaches systemic circulation across delivery formats. TD‑IntelGel™ demonstrates substantially higher relative bioavailability than conventional oral approaches.

Relative peptide bioavailability by delivery format

Tablets & capsulesVery poor or nil

Oral dissolving stripsVery poor — less than 10%

TD‑IntelGel™ buccal patchVery high — 65–90% (human clinically tested)

Injections / IVVery high — 90%, but needle-based

* Comparative delivery performance for peptides; performance may vary by peptide, formulation and study conditions.

Not simply a more convenient format — a more effective route to systemic delivery.

Explore the validation data

Beyond incremental improvement

A substantially higher level of systemic peptide availability than conventional oral formats.

Closing the delivery gap

Buccal delivery helps reduce the loss associated with the gastrointestinal pathway.

Performance that changes possibility

Higher availability expands what may be achievable through a needle‑free peptide format.

Platform applications beyond peptides

One platform. Multiple therapeutic possibilities.

TD‑IntelGel™ is a versatile delivery platform that reaches beyond peptides — supporting formulations across hormones, vaccines, oncology and more, all on one TD‑IntelGel™ buccal patch format you can develop and scale together with us.

Peptides

Proven starting point

Peptides

Needle-free, high-bioavailability delivery of fragile, temperature-sensitive peptides — the format the platform was built and clinically tested on.

Vaccines

Beyond peptides

Vaccines

A buccal route for temperature-sensitive vaccine formulations — developed to reduce the cold-chain and sharps burden of injectables.

Hormones

Beyond peptides

Hormones

Stable, patient-friendly delivery for large-molecule and temperature-sensitive hormone therapies.

Oncology

In exploration

Oncology

Exploring gentle, needle-free routes for sensitive oncology actives — developed and validated together with partners.

Built with NeoPep

The people developing on the platform.

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Research & Insights